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Yang-Hsiang Lin, Postdoctoral Fellow

Yang-Hsiang Lin

Email: yhlin0621@cgmh.org.tw

Office: 03-3281200#7785


Doctor of Philosophy                                        2008-2013

Institute of biomedical sciences, Chang Gung University, Taoyuan, Taiwan 

Master of Science                                           2006-2008

Institute of biomedical sciences, Chang Gung University, Taoyuan, Taiwan


Assistant Research Fellow                                 12/2017-present

Liver Research Center, Chang Gung Memorial Hospital, Linkou

Assistant Research Scholar                                08/2017-12/2017

Graduate Institute of Biomedical Sciences, Chang-Gung University, Taoyuan, 


Postdoctoral Fellow                                      08/2013-07/2017

Department of Biochemistry, College of Medicine, Chang-Gung University, Taoyuan, 


RESEARCH INTERESTS: Non-coding RNAs, Cancer biology, Molecular biology and Gene regulation


  1. 2015: Best Paper Award. Liver Disease Prevention & Treatment Research Foundation.
  2. 2017: Best Paper Award. Taiwan Association for the Study of the Liver


1. Chih-Lang Lin, Rong-Nan Chien, Yu-De Chu, Kung-Hao Liang, Ya-Hui Huang, Po-Yuan K, Kwang-Huei Lin, Yang-Hsiang Lin and Chau-Ting Yeh. Hepatitis B virus X gene mutants emerge during antiviral therapy and increase cccDNA levels to compensate for replication suppression. Hepatol Int. 2020 Aug 7. (YHL and CTY co-corresponding authors)

2. Yang-Hsiang Lin, Kwang-Huei Lin and Chau-Ting Yeh*. Thyroid hormone in hepatocellular carcinoma: cancer risk, growth regulation, and anticancer drug resistance. Front. Med., 2020, May 22. https://doi.org/10.3389/fmed.2020.00174

3. Yang-Hsiang Lin*. Crosstalk of lncRNA and cellular metabolism and their regulatory mechanism in cancer. Int J Mol Sci. 2020 Apr 22;21(8):2947.

4. Po-Shuan Huang, Yang-Hsiang Lin, Hsiang-Cheng Chi, Yi-Hsin Tseng, Cheng Yi Chen, Tzu-Kang Lin , Chau-Ting Yeh, Kwang-Huei Lin. Dysregulated FAM215A Stimulates LAMP2 Expression to Confer Drug-Resistant and Malignant in Human Liver Cancer. Cells. 2020 Apr 14;9(4):E961

5. Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh* and Kwang-Huei Lin*. TUG1 is a regulator of AFP and serves as prognostic marker in non-hepatitis B non-hepatitis C hepatocellular carcinoma. Cells. 2020 Feb; 9(2): 262.

6. Yang-Hsiang Lin*. MicroRNA Networks Modulate Oxidative Stress in Cancer. International Journal of Molecular Sciences. 2019 Sep 11;20(18). pii: E4497. doi: 10.3390/ijms20184497.

7. Wey-Ran Lin, Jy-Ming Chiang, Siew-Na Lim, Ming-Yao Su, Tsung-Hsing Chen, Shu-Wei Huang, Chun-Wei Chen, Ren-Chin Wu, Chia-Lung Tsai, Yang-Hsiang Lin, MalcolmR. Alison, Sen-Yung Hsieh, Jau-Song Yu, Cheng-Tang Chiu, Chau-Ting Yeh. Dynamic bioenergetic alterations in colorectal adenomatous polyps and adenocarcinomas.EBioMedicinehttps://doi.org/10.1016/j.ebiom.2019.05.031

8. Ching-Ying Chen, Sheng-Ming Wu, Yang-Hsiang Lin, Hsiang-Cheng Chi, Syuan-Ling Lin, Chau-Ting Yeh, Wen-Yu Chuang and Kwang-Huei Lin. Induction of nuclear protein-1 by thyroid hormone enhances platelet-derived growth factor A mediated angiogenesis in liver cancer. Theranostics. 2019; 9(8):2361-2379. doi:10.7150/thno.29628

9. Yu-De Chu, Hsin-Yu Lai, Li-Mei Pai, Ya-Hui Huang, Yang-Hsiang Lin, Kung-Hao Liang and Chau-Ting Yeh. The methionine salvage pathway-involving ADI1 inhibits hepatoma growth by epigenetically altering genes expression via elevating S-adenosylmethionine. Cell Death Dis. 2019 Mar; 10(3): 240.

10. Yang-Hsiang LinMeng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh, Hsiang-Cheng Chi, Chung-Ying Tsai, Wen-Yu Chuang, Chia-Jung YuI-Hsiao Chung, Ching-Ying Chen1 and Kwang-Huei Lin. Thyroid hormone negatively regulates tumorigenesis through suppression of BC200. Endocrine-Related Cancer. 2018 Dec 1;25(12):967-979. doi: 10.1530/ERC-18-0176.

11. Yang-Hsiang Lin, Meng-Han Wu, Chau-Ting Yeh, and Kwang-Huei Lin. Long non-coding RNAs as mediators of tumor microenvironment and liver cancer cell communication. International Journal of Molecular Sciences201819(12), 3742; doi:10.3390/ijms19123742

12. Po-Shuan Huang, I-Hsiao Chung, Yang-Hsiang Lin, Tzu-Kang Lin, Wei-Jan Chen, and Kwang-Huei Lin. The Long Non-Coding RNA MIR503HG Enhances Proliferation of Human ALK-Negative Anaplastic Large-Cell Lymphoma. International Journal of Molecular Sciences. 2018 May 14;19(5). pii: E1463. doi: 10.3390/ijms19051463

13. Syuan-Ling Lin, Sheng-Ming Wu, I-Hsiao Chung, Yang-Hsiang Lin, Ching-Ying Chen, Hsiang-Cheng Chi , Tzu-Kang Lin, Chau-Ting Yeh and Kwang-Huei Lin. Stimulation of Interferon-Stimulated Gene 20 by Thyroid Hormone Enhances Angiogenesis in Liver Cancer. Neoplasia. 2018 Jan;20(1):57-68. doi: 10.1016/j.neo.2017.10.007. Epub 2017 Nov 29.

14. Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh, Mei-Ling Cheng, Hsiang-Cheng Chi, Chung-Ying Tsai, I-Hsiao Chung, Ching-Ying Chen and Kwang-Huei Lin. Taurine upregulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma. Hepatology. 2018 Jan;67(1):188-203.

15. Hsiang-Cheng Chi, Shen-Liang Chen, S-L Lin, C-Y Tsai, W-Y Chuang, Yang-Hsiang Lin, Y-H Huang, M-M Tsai, C-T Yeh and K-H Lin. Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover. Oncogene. 2017 15. doi: 10.1038/onc.2017.136.

16. I-Hsiao ChungPei-Hsuan LuYang-Hsiang LinMing-Ming TsaiYun-Wen LinChau-Ting Yeh and Kwang-Huei LinThe long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma. Sci. Rep.2017. 7(1):295. doi: 10.1038/s41598-017-00382-7.

17. I-Hsiao Chung, Tzu-I Wu, Chia-Jung Liao, Jin-Yo Hu, Yang-Hsiang Lin, Pei-ju Tai, Chyong-Huey Lai, Kwang-Huei Lin. Overexpression of lipocalin 2 in human cervical cancer enhances tumor invasion. Oncotarget, 2016. 7(10), 22448-22459.

18. I-Hsiao Chung, Hsuan Liu, Yang-Hsiang Lin, Hsiang-Cheng Chi, Ya-Hui Huang , Chang-Ching Yang, Bertrand Chin-Ming Tan and K-H Lin.  ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance. Oncotarget. 2016 19;7(16):22448-59.

19. Ming-Ming Tsai, Hsiang-Wei Huang, Chia-Siu Wang, Kam-Fai Lee, Chung-Ying Tsai, Pei-Hsuan Lu, Hsiang-Cheng Chi, Yang-Hsiang Lin, Liang-Mou Kuo, and K-H Lin. MicroRNA-26b inhibits tumor metastasis by targeting the KPNA2/c-jun pathway in human gastric cancer. Oncotarget. 2016 28;7(26):39511-39526.

20. Ming-Ming Tsai, Chia-Siu Wang, Chung-Ying Tsai, Hsiang-Wei Huang, Hsiang-Cheng Chi , Yang-Hsiang Lin, Pei-Hsuan Lu and K-H Lin. Potential Diagnostic, Prognostic and Therapeutic Targets of MicroRNAs in Human Gastric Cancer. Int. J. Mol. Sci., 2016, 17(6), 945.

21. Ming-Ming Tsai, Chia-Siu Wang, Chung-Ying Tsai, Hsiang-Wei Huang, Hsiang-Cheng Chi, Yang-Hsiang Lin, Pei-Hsuan Lu and K-H Lin. Circulating microRNA-196a/b are novel biomarkers associated with metastatic gastric cancer.Eur. J Cancer. 2016, Sep;64:137-48.

22. Hsiang-Cheng Chi, Shen-Liang Chen, Yi-Hung Cheng, Tzu-Kang Lin, Chung-Ying Tsai, Ming-Ming Tsai, Yang-Hsiang Lin, Ya-Hui Huang and K-H Lin. Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway. Cell Death & Disease. 2016, 4;7(8). 

23. Sheng-Ming Wu, Syuan-Ling Lin, Kang-Yun Lee, Hsiao-Chi Chuang, Po-Hao Feng, Wan-Li Cheng, Chia-Jung Liao, Hsiang-Cheng Chi, Yang-Hsiang Lin, Chung-Ying Tsai, Wei-Jan Chen, Chau-Ting Yeh, and K-H Lin. Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression Int. J. Cancer. 2017, Apr 1;140(7):1581-1596.

24. Tseng YH, Huang YH, Lin TK, Wu SM, Chi HC, Tsai CY, Tsai MM, Lin YH, Chang WC, Chang YT, Chen WJ, and K-H Lin. Thyroid hormone suppresses expression of stathmin and associated tumor growth in hepatocellular carcinoma. Sci. Rep. 2016, 9; 6:38756. 

25. Yang-Hsiang Lin, Meng-Han Wu, Chia-Jung Liao, Ya-Hui Huang, Hsiang-Cheng Chi, Sheng-Ming Wu, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, I-Hsiao Chung, Ming-Ming Tsai, Ching-Ying Chen, Tina P. Lin, Yung-Hsin Yeh, Wei-Jan Chen and K-H Lin. Repression of microRNA-130b by thyroid hormone enhances cell motility. J Hepatology. 2015, Jun;62(6):1328-40.

26. Chia-Jung Liao, Hsiang-Cheng Chi, Chung-Ying Tsai, Chi-De Chen, Sheng-Ming Wu, Yi-Hsin Tseng, Yang-Hsiang Lin, I-Hsiao Chung, Ching-Ying Chen, Syuan-Ling Lin, Ya-Hui Huang, and K-H Lin. A novel small-form NEDD4 regulates cell invasiveness and apoptosis to promote tumor metastasis. Oncotarget. 2015, Apr 20;6(11):9341-54.

27. I-Hsiao Chung, Cheng-Yi Chen, Yang-Hsiang Lin, Hsiang-Cheng Chi, Ya-Hui Huang, Pei-Ju Tai, Chia-Jung Liao, Chung-Ying Tsai, Syuan-Ling Lin, Meng-Han Wu, Ching-Ying Chen and K-H Lin*. Thyroid hormone-Mediated Regulation of Lipocalin 2 through the Met/FAK Pathway in Liver Cancer. Oncotarget. 2015, Jun 20;6(17):15050-64.

28. Sheng-Ming Wu, Wan-Li Cheng, Chia-Jung Liao, Hsiang-Cheng Chi, Yang-Hsiang Lin, Yi-Hsin Tseng, Chung-Ying Tsai, Ching-Ying Chen, Syuan-ling Lin, Wei-Jan Chen, Yung-Hsin Yeh, Chi-Ying F. Huang, Ming-Huang Chen, Yi-Chen Yeh and K-H Lin. Negative modulation of the epigenetic regulator, UHRF1, by thyroid hormone receptors suppresses liver cancer cell growth. Inter. J. Cancer. 2015, Jul 1;137(1):37-49.

29. Yi-Hsin Tseng, Po-Yuan Ke, Chia-Jung Liao, Sheng-Ming Wu, Hsiang-Cheng Chi, Chung-Ying Tsai, Cheng-Yi Chen, Yang-Hsiang Lin and K-H Lin. Chromosome 19 Open Reading Frame 80 Is Upregulated by the Thyroid Hormone and Modulates Autophagy and Lipid Metabolism. Autophagy. 2014, 10(1), 20-31.

30. Yang-Hsiang Lin, Ya-Hui Huang, Meng-Han Wu, Sheng-Ming Wu, Hsiang-Cheng Chi, Chia-Jung Liao, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, Ming-Ming Tsai and K-H Lin*. Thyroid hormone suppresses cell proliferation through endoglin-mediated promotion of p21 stability. Oncogene. 2013, Aug 15;32(33):3904-14.

31. Yang-Hsiang Lin, Chia-Jung Liao, Ya-Hui Huang, Meng-Han Wu, Hsiang-Cheng Chi, Sheng-Ming Wu, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, I-Hsiao Chung, Tzu-I, Wu, Ming-Ming Tsai, Crystal D. Lin, and K-H Lin.Thyroid hormone receptor represses miR-17 expression to enhance tumor metastasis in human hepatoma cells.Oncogene. 2013, Sep 19;32(38):4509-18.

32. Ya-Hui Huang, Yang-Hsiang Lin, Hsiang-Cheng Chi, Chen-Hsin Liao, Chia-Jung Liao, Sheng-Ming Wu, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, Sheng-Yen Lin, Yu-Ting Hung, Chih-Jen Wang, Crystal D. Lin and K-H Lin. Thyroid hormone regulation of miR-21 enhances migration and invasion of human hepatoma cells Cancer Res.2013, 73(8) 2505-17, 2013 (YH Huang and YH Lin equal contribution).

33. C-H Liao, C-T Yeh, Y-H Huang, S-M Wu, H-C Chi, M-M Tsai, C-Y Tsai, C-J Liao, Y-H Tseng, Y-H Lin, C-Y Chen , I-H Chung, W-L Cheng, W-J Chen, K-H Lin. Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells. Hepatology. 2012, 55(3):910-20.

34. C-Y Chen, L-M Chi, H-C Chi, M-M Tsai, C-Y Tsai, Y-H Tseng, Y-H Lin, W-J Chen, K-H Lin Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)-based quantitative proteomics study of a thyroid hormone-regulated secretome in human hepatoma cells. Mol Cell Proteomics. 2012, Apr;11(4):M111.011270.

35. Hsiang-Cheng Chi, Shen-Liang Chen, Chen-Hsin Liao, Ya-Hui Huang, Ming-Ming Tsai, Chau-Ting Yeh, Sheng-Ming Wu, Chia-Jung Liao, Yi-Hsin Tseng, Yang-Hsiang Lin, Cheng-Yi Chen, Chung-Ying Tsai, I-Hsiao Chung, Wan-Li Cheng, Wei-Jan Chen, K-H Lin  A novel function of thyroid hormone receptors in promoting metastasis of human hepatoma cells via regulation of TRAIL. Cell Death and Differentiation. 2012, 19 (10): 1802-1814. 

36. Ming-Ming Tsai, Paul Y. Lin, Wan-Li Cheng, Chung-Ying Tsai, Hsiang-Cheng Chi, Cheng-Yi Chen, Yi-Hsin Tseng, Yi-Fen Cheng, Chi-De Chen, Ying Liang, Chia-Jung Liao, Sheng-Ming Wu, Yang-Hsiang Lin, I-Hsiao Chung, Chia-Siu Wang, and K-H Lin. Overexpression of ADP-Ribosylation factor 1 in Human Gastric Carcinoma and its Clinicopathological Significance Cancer Science. 2012, Jun;103(6):1136-44.

37. Wan-Li Cheng, Ming-Ming Tsai, Chung-Ying Tsai, Ya-Hui Huang, Cheng-Yi Chen, Hsiang-Cheng Chi, Yi-Hsin Tseng, Im-Wai Chao, Wei-Chi Lin, Sheng-Ming Wu, Ying Liang, Chia-Jung Liao, Yang-Hsiang Lin, I-Hsiao Chung, Wei-Jan Chen, Paul Y. Lin, and Chia-Siu Wang, K-H Lin. Glyoxalase-I is a novel prognosis factor associated with gastric cancer progression. PLoS One. 2012, 7(3): e34352. doi:10.1371/journal.pone.0034352.

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